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Anaphylaxis after hamster bites – identification of a novel allergen
Author(s) -
Lim D. L.,
Chan R. M. E.,
Wen H.,
Van Bever H. P. S.,
Chua K. Y.
Publication year - 2004
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.2004.01992.x
Subject(s) - hamster , allergen , saliva , anaphylaxis , immunology , immunoglobulin e , mesocricetus , biology , allergy , phodopus , medicine , antibody , microbiology and biotechnology
Summary Background Hamsters are popular household pets and anaphylaxis after their bites have described. However, the putative allergen has not been identified. Objective This study was conducted to identify the allergen causing dwarf hamster ( Phodopus sungoris ) bite‐induced anaphylaxis. Methods Two children with hamster bite‐induced anaphylaxis were enrolled. They both had negative results to skin testing and specific IgE to hamster epithelium. However, they were both allergic to Dermatophagoides pteronyssinus (Der p). Identification of the putative IgE‐binding allergens from the hamster saliva was performed using immunoblot analysis. Results A specific IgE‐binding component at 21 kD in the hamster saliva was identified. ELISA inhibition tests showed partial inhibition with Der p. Conclusions The putative allergen from the hamster saliva causing dwarf hamster‐induced anaphylaxis was identified. Possible cross‐reactivity with Der p was demonstrated. Further studies will be needed to identify the exact nature and function of this allergen.