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Occupational asthma caused by triglycidyl isocyanurate (TGIC)
Author(s) -
PIIRILÄ P.,
ESTLANDER T.,
KESKINEN H.,
JOLANKI R.,
LAAKKONEN A.,
PFÄFFLI P.,
TUPASELA O.,
TUPPURANEN M.,
NORDMAN H.
Publication year - 1997
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1997.tb00738.x
Subject(s) - medicine , asthma , inhalation , spirometry , occupational asthma , allergy , nose , dermatology , immunology , surgery , anesthesia
Summary Background Polyester powder paints are extensively used in metal painting. Triglycidyl isocyanurate (TGIC), an epoxy compound, is often used as a hardener. Several cases of allergic eczema from occupational exposure to TGIC have been reported in the literature. Objective We examined a 36‐year‐old non‐smoking man who worked mainly as a spray painter, using a polyester powder paint containing 4% TGIC. During painting he used protective clothing and a motorized breathing protector. After 4 years he developed eczema on his hands, face and body, and an occupational allergic eczema caused by TGIC was diagnosed. He also suffered from powder‐paint‐related asthmatic symptoms. Objective Occupational asthma was diagnosed in accordance with the accepted guidelines. Inhalation challenge tests were performed with the paint and TGIC Results Spirometry showed slight obstruction; the blood eosinophils and serum IgE value were elevated. Skin‐prick tests with common environmental allergens were negative. The challenge test with lactose powder was also negative, A challenge test with a paint containing TGIC (4%) induced a dual reaction in PEF and a late 23% fall in FEV,. A test with TGIC (4%) mixed with lactose induced a dual PEF reaction, and also dual changes in spirometry. The PD 15 in the histamine challenge test decreased significantly after the challenge tests. Conclusions To our knowledge this is the first diagnosed case of occupational asthma caused by TGIC. This case report emphasizes the importance of protecting both the skin and respiratory tract of workers against chemicals such as TGIC, capable of causing skin and respiratory allergy.