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Characterization of allergens from deer: cross‐reactivity with allergens from cow dander
Author(s) -
SPITZAUER S.,
VALENTA R.,
MÜHL S.,
RUMPOLD H.,
EBNER H.,
EBNER C.
Publication year - 1997
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1997.tb00693.x
Subject(s) - dander , cross reactivity , allergen , allergy , sensitization , immunoglobulin e , immunology , horse , chemistry , biology , cross reactions , antibody , paleontology
Summary Background Animal hair/dander proteins frequently cause Type I hypersensitivities. Species‐specific and broadly cross‐reacting allergens have been characterized in the past. Methods Sera from eight individuals suffering from symptoms due to exposure to deer and deer‐derived products were investigated by immunoblotting. Extracts from deer, dog, cat, horse, rabbit and cow, respectively, were tested for IgE‐binding. To reveal cross‐reactivities patients' sera were preadsorbed with these extracts prior to testing with deer extract. Results Deer allergens with the molecular mass of 22 and 25 kD (major allergens), as well as 60 kD were identified. The 22 and 25 kD allergens are cross‐reactive with the corresponding cow allergens. Conclusions Deer allergy is a rare sensitization mainly affecting persons exposed to deer, who displayed an atopie disposition. From our results it can be assumed that this hypersensitivity is partly associated with allergy to cow dander.