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Immunoglobulin E in acute phase response to surgical stress
Author(s) -
SZCZEKLIK A.,
JAWIEN J.
Publication year - 1996
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1996.tb00095.x
Subject(s) - medicine , immunoglobulin e , perioperative , myocardial infarction , surgery , antibody , immunology , cardiology , gastroenterology , anesthesia
Summary Background A few years ago we reported that acute myocardial infarction is associated with a distinct, transient rise in serum imtnunoglobulin (Ig)E. Objective We wondered whether this response is specific only for myocardial infarction or whether it reflects a more generalized phenomenon, precipitated by tissue injury. Methods We carried out a large prospective study on 149 patients undergoing various surgical procedures. These were the patients undergoing coronary artery bypass surgery, who did (n=39) or did not (n= 42 ) develop perioperative myocardial infarction, patients subjected to various thoracic operations ( n= 33), eholecystectotny (n = 17) or repair of the inguitial hernia (n=18). Thirty healthy volunteers fortned the control group. Results In all groups studied, except the control group, serum IgE levels began to rise shortly after the operation, reached a peak by the fifth postoperative day. and then gradually declined. This was in striking contrast to serurn imnunoglobulin G which soon alter the operation became markedly) depressed, and took more than a week to return to preoperative values. Specific IgE. against common aeroallergens, measured in a subgroup of patients with initially high total serum IgE, showed no uniform pattern of change. Conclusion Surgical operations are accompanied by a characteristic, transient rise in serum IgE concentration. Immunoglobulin E might be involved in acute phase response to tissue injury.