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Crossreactivity between Dermatophagoides siboney and other house dust mite allergens in sensitized asthmatic patients
Author(s) -
FERRÁNDIZ R.,
CASAS R.,
DREBORG S.,
EINARSSON R.,
FERNÁNDEZ B
Publication year - 1995
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1995.tb00394.x
Subject(s) - tyrophagus putrescentiae , immunoglobulin e , mite , pyroglyphidae , house dust mite , dust mites , acaridae , allergen , acari , biology , acariformes , immunology , allergy , antibody , botany
Summary Background The role of Pyroglyphid mites in IgE‐mediated serisitizalion has been well eslahlished. Although mites belonging to the genus Dermatophagoidess dominate in the acarofauna of domestic dust. non‐pyroglyphid mites might also be of clinical importance. In Cuba, Dermatophagoides siboney is found in dust coexisting with D. pteronyssiuus and Blomia tropicalis. Dermatophagoides forinae is not found. Storage mites, such as Acorus siro, Lepidoglyphus destructor and Tyrophagus putrescentiae might also be present. Objective The aim of this study was to investigate the allergenic relationships among the mites present in the environment of allergic patients in Cuba. Methods The crossreactivialty between an extract of D. siboney and the above mentioned six mites was studied by specific IgE inhibition, using sera of mite‐sensitive patients after incubation with serial dilutions of D. sibaney . Results The inhibitory effect of D. sidiney extract was more pronounced against D. farinae . 91%, than against D. pyteronyssinus , 62%. Specific IgE to B. tropicali, A. siro, L. destructor and T. putrescentiae were inhibited to a much lesser extent, i.e. between 47 and 58%. The correlation between IgE to D. siboney and IgE to D. pteronyssinus and D. farinae was of 0.92 and 0.90. respectively. A weaker correlation was found between D. siboney and L. destructor (0.7), A. siro (0.67), B. tropicalis (0.54) and T. putrescentiae (0.51). Conclusion Thus. D. siboney seems to be most closely related to D. farinae .