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Total serum IgE and FEV 1 by respiratory symptoms and obstructive lung disease in adults of a Norwegian community
Author(s) -
OMENAAS E.,
BAKKE P.,
EIDE G. E.,
ELSAYED S.,
GULSVIK A.
Publication year - 1995
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1995.tb00004.x
Subject(s) - medicine , spirometry , immunoglobulin e , obstructive lung disease , population , norwegian , respiratory system , cross sectional study , asthma , respiratory disease , pulmonary function testing , immunology , lung , copd , pathology , environmental health , antibody , linguistics , philosophy
Summary Background: The importance of total serum IgE level on lung function impairment has not been established in a general population. Objective: The aim of this cross‐sectional community study was to examine the relationship between total serum IgE and level of lung function in adults, and whether this relationship differed by sex, age, smoking habits or by respiratory symptom and disease status. Methods: A stratified random sample of 18–73 year old adults from the general population were invited to spirometry and serum analyses of total and specific IgE. Of 1512 subjects invited, 82% met and performed complete examinations. Results: Increasing level of total serum IgE was related to reduced lung function ( P <0.01) given as sex, age, and height standardized residuals of one second forced expiratory volume (SFEV 1 ). Subjects with total serum IgE in the highest vs the lowest tertile had a mean SFEV 1 of ‐0.58 vs ‐0.28, corresponding to age and height adjusted FEV 1 differences of 120 and 150mL in women and men, respectively. The relationship between IgE and lung function impairment did not differ significantly by sex, age or smoking habits. In subjects with obstructive’lung disease increasing level of total serum IgE was more negatively associated with lung function level than in subjects with respiratory symptoms alone. No relationship was observed in a symptomatic subjects. This was confirmed in a multiple linear regression analysis adjusting for sex, age, smoking habits and lifetime smoking consumption showing that SFEV 1 was predicted by an interaction between total serum IgE level and symptom and disease status (P < 0.01). This interaction remained after excluding subjects ( n = 105) having specific IgE antibodies. Conclusion: Increasing total serum IgE level was associated with progressively lower lung function in a general adult population after taking other predictors of impaired Spiro metric lung function into account, though dependent on the subjects’respiratory symptom and disease status. Variation in prevalences of respiratory symptoms and obstructive lung disease in previous examined populations may thus explain conflicting observations of the association between total IgE and airflow impairment.