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Type I allergy induced by Limulus Amoebocyte Lysate (LAL)
Author(s) -
EBNER C.,
KRAFT D.,
PRASCH F.,
STEINER R.,
EBNER H.
Publication year - 1992
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1992.tb03104.x
Subject(s) - limulus , horseshoe crab , microbiology and biotechnology , allergy , polyphemus , hemolymph , immunology , biology , medicine , dermatology , ecology , paleontology
Summary During the last few years Limulus Amoebocyte Lysate (LAL) has been extensively used to detect minimal amounts of endotoxins of Gram‐negative bacteria in products of the pharmaceutical industry, in food stuff, body fluids, house dust and room air. LAL is produced from cells of the haemolymph (amoebocytes) of the horseshoe crab ( Limulus polyphemus ), which respond with an extremely sensitive clotting system upon contact with endotoxins. In this study we demonstrate by typical case history, positive skin test and ELISA the occurrence of Type I allergy to LAL in a patient suffering from conjunctivitis and rhinitis at work.