Premium
Comparative evaluation of RAST and MAST‐CLA for six allergens for the diagnosis of inhalant allergic disease in 232 patients
Author(s) -
SCOLOZZI R.,
VICENTINI L.,
BOCCAFOGLI A.,
CAMERANI A.,
PRADELLA R.,
CAVALLINI A.,
BAGNI B.
Publication year - 1992
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1992.tb03077.x
Subject(s) - intoxicative inhalant , medicine , allergy , immunology , asthma , allergen , radioallergosorbent test , immunoglobulin e , provocation test , aeroallergen , dermatology , biology , pathology , toxicology , antibody , alternative medicine
Summary The aim of this study was to compare a recent multiple allergosorbent chemiluminescent assay (MAST‐CLA) with the RAST for the diagnosis of inhalant allergic disease in 232 patients with rhinitis and/or bronchial asthma. As judged by concordance of clinical history, skin prick tests to a range of six allergens common to our geographic area, and by nasal provocation tests, 70 patients were non‐allergic and 162 allergic: 70 to grasses, 46 to mites, four to mugwort, eight to pellitory, and 34 were sensitive to several allergens. In our patient sample that, among other things, comprises subjects with fairly rare monoallergies, MAST‐CLA testing gave results which closely corresponded to positive RAST for the allergens studied, and demonstrated a close correlation with the diagnosis of inhalant‐specific allergy. Our results showed that, for overall allergens, MAST‐CLA was lightly less sensitive and more specific than RAST (the two in vitro tests gave an identical overall efficiency).