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Bronchial responsiveness to exercise in a random sample of 494 children and adolescents from Copenhagen
Author(s) -
BACKER V.,
ULRIK C. S.
Publication year - 1992
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1992.tb02813.x
Subject(s) - bronchoconstriction , bronchial hyperresponsiveness , asthma , medicine , histamine , population , physical exercise , exercise induced asthma , physical therapy , treadmill , respiratory disease , lung , environmental health
Summary To investigate the bronchial response to exercise, we studied a random sample of 494 children and adolescents, aged 7–16 years, from Copenhagen. Exercise challenge consisted of steady running on a 10% sloping treadmill for 6 min in a climate chamber. Furthermore, in 464 subjects a histamine challenge test was also performed. Of the 494 subjects studied, 81 (16%) had at least 10% and 30 (6%) at least 15% reduction in FEV 1 within 15 min after exercise. Twenty‐nine (6%) subjects had bronchial hyperresponsiveness to both histamine and exercise, 48 (10%) subjects had bronchial hyperresponsiveness to exercise, but histamine responsiveness within the normal range, whereas 340 (73%) subjects had neither bronchial hyperresponsiveness to exercise nor inhaled histamine. With regard to the presence of asthma defined as substantial exercise induced bronchoconstriction (Δ‐FEV 1 ≥10%), exercise testing may not be appropriate for identifying clinical asthma in a random sample, because the highest predictive value of a positive lest was 25%. On the other hand, a history of clinical asthma was frequently associated with increased bronchial responsiveness to exercise (77%). In conclusion, 16% of a random sample of children and adolescents had abnormal bronchial responsiveness to exercise (ΔFEV 1 ≥10%), 6% of the subjects had a ΔFEV 1 ≥15%. Furthermore, because of a low predictive value of a positive test, the exercise challenge test has only a supplementary role in the detection of clinical asthma in population samples.