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The effect of intranasal azelastine, Rhinolast®, on nasal airways obstruction and sneezing following provocation testing with histamine and allergen
Author(s) -
THOMAS K. E.,
OLLIER S.,
FERGUSON H.,
DAVIES R. J.
Publication year - 1992
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1992.tb00182.x
Subject(s) - azelastine , provocation test , medicine , histamine , allergen , rhinomanometry , nasal provocation test , antihistamine , nasal administration , placebo , allergy , anesthesia , tryptase , pharmacology , nose , immunology , mast cell , surgery , pathology , alternative medicine
Summary The effect of single dose topical nasal therapy with azelastine hydrochloride (azelastine) on the response of nasal airways resistance (NAR) to provocation testing was studied in 36 patients with seasonal allergic rhinitis. Nasal provocation testing (NPT) with histamine or grass pollen was performed after a single dose of azelastine, 0.28 mg to each nostril, or placebo. NAR was assessed by rhinomanometry for 10 hr following NPT. Compared to placebo the NAR response to histamine was inhibited at both 1 and 2 hr following azelastine administration, significant at 1 hr ( P < 0.02) and 2 hr ( P < 0.0001). No such effect was observed in relation to allergen‐induced changes in NAR. Azelastine also inhibited numbers of sneezes for up to 10 hr following both histamine NPT ( P < 0.02) and allergen NPT ( P < 0.05), when compared to placebo. Forty‐seven per cent of participants experienced bitter or unpleasant taste sensations after azelastine administration but no other unwanted effects were clearly related to azelastine therapy.