Premium
A double‐blind controlled trial of hyposensitization to Dermatophagoides pteronyssinus in children with atopic eczema
Author(s) -
GLOVER M. T.,
ATHERTON D. J.
Publication year - 1992
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1992.tb00145.x
Subject(s) - medicine , placebo , double blind , allergy , dermatology , clinical trial , randomized controlled trial , immunology , alternative medicine , pathology
Summary A double‐blind controlled trial of hyposensitization with tyrosine‐adsorbed Dermatophagoides pteronyssinus vaccine in 24 children with atopic eczema and immediate hypersensitivity to D. pteronyssinus failed to demonstrate superiority over placebo after a standard 8 month course of treatment. In a second phase, children initially administered active treatment were randomly allocated to continue with active treatment or switched to placebo for a further 6 months. The clinical scores suggest that prolonged hyposensitization may be more effective than placebo but the numbers were too small to permit confident conclusions. A dramatic placebo effect may have served to conceal any additional therapeutic effect from active treatment.