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Selenium status in relation to reduced glutathione peroxidase activity in aspirin‐sensitive asthma
Author(s) -
PEARSON D. J.,
SUAREZMENDEZ V. J.,
DAY J. P.,
MILLER P. F.
Publication year - 1991
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1991.tb00831.x
Subject(s) - asthma , selenium , glutathione peroxidase , aspirin , platelet , selenium deficiency , peroxidase , glutathione , medicine , endocrinology , chemistry , immunology , enzyme , biochemistry , organic chemistry
Summary Selenium status and its relationship to lowered platelet glutathione peroxidase activity was investigated in 18 subjects with aspirin (ASA)‐induced asthma and in asthmatic and non‐asthmatic ASA‐tolerant subjects. Mean serum selenium concentration in ASA‐toleranl asthmatics (1.25 μm; 98.5 μg/1) was significantly higher than that in ASA‐induced asthma subjects (1.14μm/l; 89.7μg/1) and than that in healthy controls (1.15 μm/1.91 μg/1). Although there was a correlation between serum selenium concentration and platelet glutathione peroxidase activity, enzyme activity was significantly lower in the ASA‐induced asthma group compared to other groups even after correcting for selenium status. These results indicate that lowered platelet glutathione peroxidase activity in ASA‐induced asthma is a product of both selenium availability and an unidentified syndrome‐specific (possibly genetic) factor.