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Inhibitory effect of inhaled procaterol on anaphylactic bronchoconstriction and thromboxane A 2 production in guinea‐pigs
Author(s) -
FUJIMURA M.,
SAKAMOTO S.,
NISHI K.,
SAITO M.,
MIYAKE Y.,
MATSUDA T.
Publication year - 1991
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1991.tb00829.x
Subject(s) - bronchoconstriction , bronchoalveolar lavage , inhalation , thromboxane , pharmacology , thromboxane a2 , thromboxane b2 , agonist , guinea pig , medicine , immunology , ovalbumin , chemistry , asthma , lung , antigen , endocrinology , anesthesia , receptor , platelet
Summary This study was designed to examine whether an inhaled β 2 ‐agonist, procaterol, inhibits thromboxane A 2 (TXA 2 ) production induced by antigen challenge in passively sensitized guinea‐pigs in vivo . Antigen‐induced bronchoconstriction was markedly inhibited by pre‐treatment with procaterol. Inhaled procaterol significantly reduced in a dose‐dependent manner the increment in TXB 2 concentration in bronchoalveolar lavage fluid obtained 5 min after antigen challenge. Aerosol administration of procaterol significantly inhibited bronchoconstriction induced by inhaled hislainine. These results suggest that inhalation of procalerol has an inhibitory effect on antigen‐induced TXA 2 production as well as a protective effect against bronchoconstriction induced by bronchoactive agents.