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Relationship between IgG 1 and IgG 4 antibodies to foods and the development of IgE antibodies to inhalant allergens. II. Increased levels of IgG antibodies to foods in children who subsequently develop IgE antibodies to inhalant allergens
Author(s) -
CALKHOVEN P. G.,
AALBERS MARJA,
KOSHTE V. L.,
SCHILTE P. P. M.,
YNTEMA J. L.,
GRIFFIOEN R. W.,
NIEROP J. C.,
ORANJE A. P.,
AALBERSE R. C.
Publication year - 1991
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1991.tb00810.x
Subject(s) - immunoglobulin e , immunology , antibody , medicine , intoxicative inhalant , mite , allergy , biology , toxicology , botany
Summary In the present investigation we have tested the hypothesis that children with a high IgG antibody response to foods have an increased risk of developing IgE antibodies to inhalant allergens. Sera from 106 children with an increased risk of developing IgE‐mediated allergy were analysed. During the follow‐up, in 54 of these children IgE antibodies to inhalant allergens appeared. A positive/negative IgG 1 and IgG 4 anti‐food score was determined as described previously: sera from age‐clustered unselected children were tested for the levels of IgG 1 and IgG 4 antibodies to common foods. For each IgG RAST and each age group, the 75‐percentile was chosen as cut‐off value. Each antibody level was thus converted into a positive (higher than the 75‐percentile of the age group) or negative value. The number of positive tests was used as the score. High‐risk children with a high IgG 1 anti‐food score more often developed inhalant‐specific IgE antibodies than high‐risk children with low IgG 1 titres: 50% of the children with a high IgG 1 anti‐food score developed IgE antibodies to grass pollen, whereas only 16% of the children with a low IgG 1 anti‐food score acquired IgE anti‐grass pollen. Fifty percent of the children with a high and 14% of the children with a low IgG 1 anti‐food score developed IgE antibodies to cat dander. For the prediction of the development of IgE anti‐mite (house dust mite), the IgG 4 anti‐food scores appeared less useful than the IgG 1 anti‐food scores; 46% of the IgG 4 high responders versus 22% of the IgG 4 low responders acquired IgE anti‐mite, whereas for IgG 1 these precentages were 73 and 19, respectively.