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House dust mite allergen levels and an anti‐mite mattress spray (natamycin) in the treatment of childhood asthma
Author(s) -
REISER J.,
INGRAM D.,
MITCHELL E. B.,
WARNER J. O.
Publication year - 1990
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1990.tb03150.x
Subject(s) - house dust mite , placebo , medicine , asthma , allergen , lavender , allergy , mite , inhalation , natamycin , toxicology , anesthesia , immunology , biology , food science , botany , alternative medicine , pathology , essential oil
Summary Natamycin, a fungicide marketed as Tymasil, is claimed to reduce house dust mite numbers and would therefore be expected to improve asthma in children with mite sensitivity. We have tested this assertion by a double‐blind, placebo‐controlled trial. There was no significant effect on levels of Der p I in mattress dust between active and placebo groups at the end of the spraying period. Histamine inhalation challenge PC 20 , clinic visit symptom scores and lung function tests reflecting either large or small airways obstruction were also unchanged. Therefore this product is not a therapeutic option for mite‐allergic patients using the manufacturer's recommended dose and method of administration. Other factors influencing the Der p I levels were also investigated. Of these, only month of measurement and bedroom wall humidity showed any association.