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The spectrum of low molecular weight house dust mite ( Dermatophagoides pteronyssinus ) allergens with emphasis on Der p II
Author(s) -
FORD S. A.,
TOVEY E. R.,
BALDO B. A.
Publication year - 1990
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1990.tb02771.x
Subject(s) - allergen , immunoglobulin e , house dust mite , pyroglyphidae , mite , immunology , blot , antibody , chemistry , allergy , microbiology and biotechnology , biology , biochemistry , ecology , gene
Summary Analysis by protein blotting of sera from 96 different house dust mite‐allergic subjects revealed previously unrecognized complexity of low molecular weight (MW) (< 20 kD) IgE‐binding proteins in extracts of whole bodies of Dermatophagoides pteronyssinus. Of 11 different IgE‐binding components of MW < 20 kD identified, two (MW ∼ 16 kD and ∼ 15 kD), showed both a high frequency (88% and 49% respectively) and a high intensity of IgE‐binding. The ∼ 16 kD component, identified as allergen Der p II, showed the highest frequency of IgE antibody reactivity of any of the major D. pteronyssinus allergens including Der p I and Der p III.