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Does reversed‐type anaphylaxis in healthy subjects mimic a real allergic reaction?
Author(s) -
HENOCQ E.,
RIHOUX J.P.
Publication year - 1990
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1990.tb02682.x
Subject(s) - terfenadine , cetirizine , medicine , allergy , eosinophil , anaphylaxis , immunoglobulin e , basal (medicine) , immunology , pharmacology , asthma , antibody , insulin
Summary Immediate and late cutaneous reactions were induced in healthy and atopic subjects by anti‐IgE challenge and a skin‐window technique was used in order to verify if the pattern of cells observed at 24 hr was similar in both groups. The study was first performed under basal conditions, and in a second double‐blind cross‐over step, it was performed again during treatment with cetirizine 10 mg b.i.d. and terfenadine 60 mg b.i.d. Anti‐IgE challenge was followed by a significant eosinophil accumulation in atopic subjects only. Cetirizine significantly inhibited this phenomenon while terfenadine showed a mild nonsignificant inhibitory effect.