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Effect of cetirizine in a conjunctival provocation test with allergens
Author(s) -
SCHOENEICH MAGDALENA,
PÉCOUD A. R.
Publication year - 1990
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1990.tb02663.x
Subject(s) - cetirizine , provocation test , itching , placebo , medicine , terfenadine , allergen , dermatology , anesthesia , allergy , antagonist , antihistamine , allergic conjunctivitis , pharmacology , immunology , alternative medicine , receptor , pathology
Summary Cetirizine is a new selective H 1 ‐antagonist. In a double‐blind and placebo‐controlled study, 11 subjects underwent a conjunctival provocation test (CPT) with a grass pollen extract to determine the effect of cetirizine on allergen‐induced itching and redness of the eye. Results of CPTs were reproducible, as no difference was observed between the CPTs performed without any pre‐treatment and the CPTs after placebo. Compared to placebo, cetirizine administered orally (10 mg twice a day for 4 days) and in double‐blind fashion increased the conjunctival reaction threshold ( P < 0.004) by inhibiting both redness and itching of the eye. Cetirizine should protect patients against allergic conjunctivitis.