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Neuropeptides, mast cells and allergy: novel mechanisms and therapeutic possibilities
Author(s) -
GOETZL E. J.,
CHENG P. P. J.,
HASSNER A.,
ADELMAN D. C.,
FRICK O. L.,
SREEDHARAN S. P.
Publication year - 1990
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1990.tb02469.x
Subject(s) - allergy , neuropeptide , immunology , medicine , mast cell , neuroscience , mast (botany) , biology , receptor
Summary Diverse neuropeptides are released by neuroendocrine and immune cells at the sites of allergic and inflammatory reactions. The neuropeptides and other neuromediators affect functions of smooth muscle, microvasculature and secretory cells, and are potent stimuli of mast cell, lymphocyte and other leucocyte contributions to such reactions. The distinctive immune sources, structures and cellular receptors for neuromediators suggest the possibility of novel pathogenetic mechanisms and levels of pharmacological intervention specific for neuroregulation of immunity and hypersensitivity.