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Double‐blind cross‐over trial comparing beclomethasone dipropionate and terfenadine in perennial rhinitis
Author(s) -
ROBINSON A. C.,
CHERRY J. R.,
DALY SUSAN
Publication year - 1989
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1989.tb02437.x
Subject(s) - terfenadine , medicine , beclometasone dipropionate , nasal spray , double blind , nose , anesthesia , nasal administration , pharmacology , surgery , respiratory disease , placebo , alternative medicine , pathology , lung
Summary Eighteen patients with perennial rhinitis were evaluated in this double‐blind cross‐over trial comparing beclomethasone dipropionate (BDP) aqueous nasal spray with terfenadine tablets. Both treatments were effective in reducing symptom scores but BDP was significantly better than terfenadine in relieving running nose and sneezing ( P <0.05). BDP also had a greater effect on reducing nasal inflammation than terfenadine. Although the clinicians and patients assessed both therapies to be equieffective, significantly more patients preferred the BDP treatment ( P <0.003). Overall, BDP therapy proved more beneficial than terfenadine therapy in this small group of perennial rhinitis sufferers.