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Inhibitory effect of terfenadine on mediator release from human blood basophils and eosinophils
Author(s) -
NABE M.,
AGRAWAL D. K.,
SARMIENTO E. U.,
TOWNLEY R. G.
Publication year - 1989
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1989.tb02426.x
Subject(s) - terfenadine , histamine , chemistry , pharmacology , histamine h1 receptor , allergy , immunoglobulin e , basophil , immunology , medicine , biochemistry , antagonist , receptor , antibody
Summary The effect of terfenadine on histamine release from human basophils and LTC 4 production and release from human eosinophils was evaluated. Eosinophils and basophils were obtained by discontinuous gradient centrifugation of the peripheral blood of atopic asthma patients who were off medication. Anti‐IgE‐induced histamine release from human basophils was significantly inhibited by terfenadine. Maximum inhibition was obtained at 1 × 10– 5 m terfenadine (percentage inhibition = 57.0 ± 20.1; P < 0.05). However, only the highest dose of terfenadine used in this study, i.e. 2 × 10– 5 m , significantly inhibited calcium ionophore (A23I87)‐induced histamine release from human basophils (percentage inhibition = 40.0 ± 14.6; P < 0.05), and LTC 4 production from human eosinophils (percentage inhibition = 59.8 ± 9.9; P < 0.05. These findings demonstrate that terfenadine, in addition to its known antihistaminic property, also has an inhibitory effect on chemical mediator release.