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Leukotriene E 4 release in cold urticaria
Author(s) -
MALTBY N. H.,
IND P. W.,
CAUSON R. C.,
FULLER R. W.,
TAYLOR G. W.
Publication year - 1989
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1989.tb02340.x
Subject(s) - histamine , leukotriene , leukotriene e4 , leukotriene c4 , immunology , pathogenesis , leukotriene b4 , leukotriene d4 , medicine , common cold , chemistry , endocrinology , asthma , inflammation
Summary Cold urticaria is a rare condition characterized by abnormal wealing following exposure to cold. It has been suggested that lipid‐derived mediators may be involved in the pathogenesis of this condition. We have investigated whether the inflammatory reaction in cold urticaria is associated with the release of cysteinyl‐leukotrienes. Leukotriene E 4 (LTE 4 ; a stable metabolic product of LTC 4 and LTD 4 ) and histamine were measured in the blood draining the site of a cold‐challenge in five patients with clinical histories of cold urticaria. Three of the patients showed a typical clinical response to the challenge, and this was associated with an increase in the concentration of LTE 4 and histamine. No increase in LTE 4 or histamine levels were observed following cold challenge in the non‐responding individuals.