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Clinical manifestations of cows’ milk allergy in childhood. I. Associations with in‐vitro cellular immune responses
Author(s) -
HILL D. J.,
BALL GERALDINE,
HOSKING C. S.
Publication year - 1988
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1988.tb02897.x
Subject(s) - milk allergy , ingestion , medicine , irritability , casein , allergy , cow's milk allergy , immune system , elimination diet , food allergy , immunology , gastroenterology , physiology , food science , biology , menopause
Summary In this study 51 children who presented with symptoms of cows’ milk allergy (CMA) were categorized clinically by their response to cows’ milk challenge. Forty‐two patients had unequivocal evidence of CMA and nine were milk tolerant. Of the patients with CMA two groups were identified. The first, made up of 32 patients, had immediate‐type hypersensitivity reactions to milk associated with both positive skin‐prick test (SPT) and RAST. The second group of 10 late reacting patients developed symptoms of CMA over several hours or days; significant increases in irritability, frequency of bowel actions, and rhinitis following milk ingestion were noted in this group. Leucocyte inhibition factor (LIF) produced in response to α‐lactalbumin, β‐lactoglobulin and α‐casein was assessed in the immediate and late reacting CMA patients as well as in the milk‐tolerant group. There was no difference in LIF production between the milk‐tolerant group and those with immediate reactions. However, these two groups produced less LIF than the late reacting patients for α‐lactalbumin ( P = 002), α‐casein ( P = 0.03) and β‐lactoglobulin ( P = 0.05). A clinical diary score card was found to be a useful instrument to assess the response of non‐immediate reactions to milk ingestion.