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Cross‐reaction between aromatic isocyanates (TDI and MDI): a specific bronchial provocation test study
Author(s) -
INNOCENTI A.,
CIRLA A. M.,
PISATI G.,
MARIANO A.
Publication year - 1988
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1988.tb02879.x
Subject(s) - provocation test , cross reactions , asthma , medicine , immunology , pathology , antigen , alternative medicine
Summary A study was performed on twenty‐five workers exposed to polyurethane varnishes exclusively catalysed with TDI, who developed asthma to this substance. The aim of the study was to establish, using bronchial provocation tests, whether a cross‐response to MDI exists. The results were positive but no definitive evidence has been reached because there was cross‐response in only 48% of cases. It is interesting, however, that cross‐responders did not predominate among the subjects with a late reaction to TDI ( P = 0.0038), whereas cross‐responders were in the majority among the subjects with a dual reaction to TDI ( P = 0.0334). It is possible that the pattern of the asthmatic reaction to BPT with TDI influences the cross‐reaction to other isocyanates.