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Systemic adrenaline attenuates skin response to antigen and histamine
Author(s) -
WARREN J. B.,
McCUSKER M.,
FULLER R. W.
Publication year - 1988
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1988.tb02859.x
Subject(s) - histamine , medicine , forearm , endocrinology , antigen , saline , allergy , epinephrine , immunology , chemistry , pathology
Summary Six atopic subjects received either adrenaline (0.3 ml of 1 mg/ml), subcutaneously over the deltoid muscle, or saline on 2 separate days. After 10 min, histamine and antigen were injected intradermally in the forearm. Adrenaline significantly inhibited the flare of histamine and both the flare and weal of antigen ( P < 0.05). This anti‐allergic action of adrenaline occurred with a dose that we have previously shown produces plasma concentrations at the upper limit of the physiological range in resting normal subjects.