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Histamine and methacholine do not increase nasal reactivity
Author(s) -
GRØNBORG H.,
BORUM P.,
MYGIND N.
Publication year - 1986
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1986.tb01999.x
Subject(s) - methacholine , provocation test , histamine , nasal provocation test , allergen , medicine , nasal administration , immunology , asthma , airway resistance , allergy , nose , respiratory disease , lung , pathology , surgery , alternative medicine
. Allergen provocation in the nose increases the non‐specific nasal reactivity. The aim of this trial was to determine whether this‘priming effect’ can be caused by histamine or methacholine, which is the most important biochemical mediator of allergic rhinitis, and an analogue to the important neurotransmittor, acetylcholine, respectively. Intranasal provocation tests with the two substances were carried out on thirteen normal subjects, and repeated 1 hr and 1 day later. The response, measured as the number of sneezes, the amount of blown secretion and the increase in nasal airway resistance, did not change with consecutive provocations. It was concluded that neither histamine nor methacholine were responsible for the allergen‐induced‘priming’ of the nasal mucous membrane.