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Stimulation of IgE sensitized human alveolar macrophages by anti‐IgE is unaffected by sodium cromoglycate
Author(s) -
FULLER R. W.,
MACDERMOT L.
Publication year - 1986
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1986.tb01990.x
Subject(s) - immunoglobulin e , sodium cromoglycate , stimulation , immunology , chemistry , thromboxane , sensitization , medicine , asthma , antibody , endocrinology , platelet
. Sodium cromoglycate is an effective prophylactic in the treatment of asthma. However, its mechanism of action is still uncertain. The release of thromboxane B 2 and N‐acetyl‐β‐D‐glucosaminidase activity was measured from human alveolar macrophages sensitized with human myeloma IgE. Cells were challenged with rabbit affinity purified anti‐IgE (no activity against IgG) in the absence or presence of sodium cromoglycate (10 ‐4 ‐10 ‐8 M). There was no change in the release of either thromboxane B 2 or N‐acetyl‐β‐D‐glucosaminidase in the presence of sodium cromoglycate at these concentrations.