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Detection of thiopentone‐reactive IgE antibodies following anaphylactoid reactions during anaesthesia
Author(s) -
HARLE D. G.,
BALDO B. A.,
SMAL M. A.,
WAJON P.,
FISHER M. M.
Publication year - 1986
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1986.tb01984.x
Subject(s) - immunoglobulin e , barbiturate , antibody , medicine , radioimmunoassay , anaphylactoid reactions , methohexital , drug , immunology , pharmacology , allergy , chemistry , anaphylaxis , anesthesia , propofol
Summary A radioimmunoassay was developed to detect IgE antibodies to the anaesthetic induction agent thiopentone. Significant levels of thiopentone‐reactive IgE antibodies were found in the sera of two patients who had experienced life‐threatening anaphylactoid reactions following administration of the drug. Inhibition experiments revealed that cross‐reactivity occurs between the drug‐reactive IgE antibodies and four barbiturate analogues pentobarbitone, phenobarbitone, barbitone and methohexital. The assay should supplement skin testing for the detection of patients with potentially lethal sensitivity to thiopentone.