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Associations between asthma history, atopy, and non‐specific bronchial responsiveness in young adults
Author(s) -
COOKSON W. O. C. M.,
MUSK A. W.,
RYAN G.
Publication year - 1986
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1986.tb01977.x
Subject(s) - atopy , asthma , wheeze , medicine , methacholine , etiology , immunology , first degree relatives , family history , population , allergy , respiratory disease , lung , environmental health
Summary In 105 subjects taken from a student population and aged between 15 and 30 there was a strong positive association between the presence of the atopic state, defined by skin tests, and a high level of non‐specific bronchial responsiveness to methacholine (χ 2 = 10·5, d.f. = 2, P = 0·01). Regression analysis showed a history of asthma, and the symptom of wheeze, to be predominantly predicted by the degree of bronchial responsiveness (R 2 = 31%), with only a minor independent contribution from the degree of atopy ( R 2 a furthur 5%). The genetic or other reasons for the association between bronchial responsiveness and atopy may have importance in understanding the aetiology of allergic asthma.