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Immunoglobulin substitution therapy in a patient with primary hypogammaglobulinaemia and anti‐IgA antibodies
Author(s) -
HEDDERICH U.,
KRATZSCH G.,
STEPHEN W.,
DICHTELMÜLLER H.,
OLISCHLÄGER K.,
HEIMPEL H.
Publication year - 1986
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1986.tb01966.x
Subject(s) - antibody , medicine , common variable immunodeficiency , immunology , substitution therapy , immunoglobulin a , intravenous immunoglobulin therapy , immunoglobulin e , immunodeficiency , respiratory tract infections , immunoglobulin g , respiratory system , immune system
Summary Permanent immunoglobulin substitution therapy was performed in a 44‐year‐old patient with common variable immunodeficiency, recurrent respiratory tract infections, total absence of serum IgA and a high titre of class‐specific anti‐IgA antibodies. An IgA‐depleted i.v. immunoglobulin (IG) preparation was used. Infusions were well tolerated by the patient although minor anaphylactoid symptoms regularly occurred. Anti‐IgA antibody titres rose during the first 4 months of treatment and gradually fell during the following 8 months. Regular IG substitution therapy led to a substantial improvement in the patient's health and quality of life.