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IgE antibody‐mediated shock reaction caused by topical application of chlorhexidine
Author(s) -
OHTOSHI T.,
YAMAUCHI N.,
TADOKORO K.,
MIYACHI S.,
SUZUKI S.,
MIYAMOTO T.,
MURANAKA M.
Publication year - 1986
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1986.tb00759.x
Subject(s) - chlorhexidine , immunoglobulin e , radioallergosorbent test , antibody , medicine , immunology , chemistry , microbiology and biotechnology , dentistry , biology
Summary A case of an anaphylactic shock following topical application of chlorhexidine preparation is reported. Specific skin‐sensitizing antibodies against chlorhexidine were demonstrated in the serum from the patient by a passive transfer test. IgE antibodies against chlorhexidine were also detected by radioallergosorbent technique (RAST). Paper discs conjugated with chlorhexidine‐HSA (human serum albumin) significantly bound the IgE antibodies. Furthermore, all of the sera from seven other patients with shock reactions following the topical application of chlorhexidine preparation also showed high RAST counts. Both chlorhexidine gluconate and chlorguanide which represents approximately half a molecule of chlorhexidine inhibited the reaction in a dose‐dependent fashion. It is suggested that the shock reactions following topical application of chlorhexidine are mediated by IgE antibodies against chlorhexidine and that chlorhexidine and chlorguanide share the same antigenic determinant.