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Attenuation of exercise‐induced asthma by pretreatment with nedocromil sodium and minocromil
Author(s) -
ROBERTS J. A.,
THOMSON N. C.
Publication year - 1985
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1985.tb03006.x
Subject(s) - nedocromil sodium , placebo , asthma , exercise induced asthma , medicine , nedocromil , anesthesia , alternative medicine , pathology
Summary In a group of atopic adult asthmatic patients the effects of two new inhaled anti‐asthmatic drugs, nedocromil sodium and minocromil were studied in two independent randomized double‐blind trials to assess their efficacy in preventing exercise‐induced asthma (EIA). Exercise testing consisted of steady state running on an inclined treadmill. Neither drug administered 30 min before exercise significantly altered baseline FEV 1 . Nedocromil sodium (2 and 4 mg) pre‐treatment in nine patients and minocromil (4 mg) in eight patients gave significant protection ( P < 0.001) compared to placebo as assessed by the reduction in the maximum percentage fall in FEV 1 . There was no significant difference in the inhibitory effect of the two doses of nedocromil sodium. These results indicate that both nedocromil sodium and minocromil can attenuate EIA.