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Gastrointestinal permeability in atopic and non‐atopic mothers, assessed with different‐sized polyethyleneglycols (PEG 400 and PEG 1000)
Author(s) -
FÄLTHMAGNUSSON KARIN,
KJELLMAN N.I. M.,
SUNDQVIST T.,
MAGNUSSON K.E.
Publication year - 1985
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1985.tb02310.x
Subject(s) - medicine , peg ratio , allergy , intoxicative inhalant , sensitization , atopy , intestinal permeability , immunology , gastroenterology , dermatology , biology , toxicology , finance , economics
Summary Gastrointestinal permeability was compared in seventy‐one women, forty‐six allergic and twenty‐five non‐allergic according to case history, by measuring the 6‐hr urinary recovery after an oral load of different‐sized polyethyleneglycols (PEG 400 and PEG 1000). Further classification, atopic and non‐atopic, was obtained by skin‐prick tests to inhalant and food allergens in sixty‐four of the seventy‐one mothers. No significant differences were observed between allergic and non‐allergic women, neither regarding the maximum recovery nor the recovery ratio between a large and a small molecule. The results do not lend support to the hypothesis of a persistently increased gut permeability in atopic subjects, which in turn could possibly imply an increased risk of intrauterine sensitization of the foetus of an atopic mother.