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Effects of verapamil and sodium cromoglycate on bronchoconstriction induced by isocapnic hyperventilation
Author(s) -
RAFFERTY P.,
FERGUSSON R. J.,
TWEEDDALE P. M.,
BIGGS B. A.,
GRANT I. W. B.
Publication year - 1985
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1985.tb02306.x
Subject(s) - hyperventilation , bronchoconstriction , sodium cromoglycate , verapamil , cromolyn sodium , medicine , bronchodilation , anesthesia , asthma , pharmacology , airway , bronchodilator , calcium
Summary Twenty‐four patients who were known to develop bronchoconstriction in response to isocapnic hyperventilation (IH) took part in a double‐blind, placebo‐controlled trial to assess the effects of verapamil (5 mg) and sodium cromoglycate (SCG) 20 mg in the prevention of IH‐induced bronchoconstriction. Both drug and placebo were inhaled in dry powder form and responses were assessed by serial measurements of forced expiratory volume in 1 sec (FEV 1 ). Sodium cromoglycate was shown to offer significant protection whereas verapamil powder provoked bronchoconstriction in over 40% of patients and these patients appeared to be those with more marked degrees of bronchial reactivity.