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IgE and IgG4 antibodies to bovine milk fat globule membrane in atopic eczema patients: a study of their occurrence, relevance and antigenic specificity
Author(s) -
SHAKIB F.,
BROWN H. MORROW,
REDHEAD R.,
PHELPS A.
Publication year - 1985
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1985.tb02284.x
Subject(s) - immunoglobulin e , antibody , atopic dermatitis , immunology , milk allergy , allergy , medicine , antigen , clinical significance , casein , biology , food science
Summary IgE and IgG4 antibodies to bovine milk fat globule membrane (FGM) were measured in atopic eczema patients to determine whether their presence would account for allergy to milk in cases where whole or individual milk protein‐specific antibodies are not detectable. The study demonstrates that the measurements of IgE and IgG4 antibodies to FGM do not offer any additional diagnostic value in milk exacerbated cases of atopic eczema. Furthermore, cross‐inhibition studies with four milk proteins showed that these FGM‐reactive IgE and IgG4 antibodies are directed against α‐casein.