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Effect of disodium cromoglycate on anti‐IgE induced early and late skin response in humans
Author(s) -
GRÖNNEBERG R.,
ZETTERSTRÖM O.
Publication year - 1985
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1985.tb02270.x
Subject(s) - disodium cromoglycate , immunoglobulin e , medicine , mast cell , immunology , drug , asthma , pharmacology , antibody
Summary The effect of the anti‐allergic drug disodium cromoglycate (DSCG) on immediate and late responses to anti‐human IgE was examined in thirteen healthy subjects. DSCG, 250 μg, applied intradermally together with anti‐IgE had no effect on the immediate flare and weal response, whereas the following late phase response, 1–24 hr, was attenuated by 15% ( P >0 05, at 6 hr p >0.01). This effect varied between individuals ( p >0.01) and was reproduced in a second trial in DSCG‐responders and non‐res‐ponders ( P > 0.01, n =8). The results support the view that DSCG has no effect on the immediate mast cell derived response in human skin but can inhibit the development of late reactions. This mechanism might account for some of the anti‐allergic effects of the drug.