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Specific IgG subclass antibodies, IgE and IgG S‐TS antibodies to wheat gluten fraction B in patients with coeliac disease
Author(s) -
RAWCLIFFE P. M.,
JEWELL D. P.,
FAUX J. A.
Publication year - 1985
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1985.tb02268.x
Subject(s) - coeliac disease , antibody , immunoglobulin e , immunology , medicine , subclass , immunoglobulin g , immunopathology , gluten , gliadin , disease , pathology
Summary Antibodies were measured in the sera of fifteen patients with untreated coeliac disease and twenty‐eight patients with inflammatory bowel disease. Increased levels of specific IgG, IgG 1 , IgG 2 , and IgG 4 antibody to wheat gluten fraction B, measured by an enzyme‐linked immunosorbent assay, were shown in the coeliac disease group, but not in the inflammatory bowel disease group. No specific IgE antibody to fraction B was detected but 33% of the patients with coeliac disease had specific short‐term sensitizing (anaphylactic) IgG antibody activity (IgG S‐TS) to fraction B. There was no correlation between the IgG 2 or IgG 4 specific antibody and the presence of IgG S‐TS activity.