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Collaborative clinical assay of the biological potency of allergen skin‐test extracts
Author(s) -
CARREIRA J.,
RUBIO M.,
HERRERO T.,
HORAK F.,
BUSINCO L.,
WÜTHRICH B.,
PRADA V. BEARZI,
BERRY J. B.,
LISCHKA G.,
BRIGHTON W. D.
Publication year - 1984
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1984.tb02236.x
Subject(s) - potency , allergen , skin test , antigen , mite , bioassay , medicine , pharmacology , immunology , chemistry , biology , allergy , botany , in vitro , biochemistry , pathology , ecology , tuberculosis
Summary A multicentre collaborative clinical trial has been made at one centre in each of six countries to decide if the potency of allergen extracts can be determined satisfactorily by skin‐prick tests in man. Although there was considerable variation in potency of antigen when determined in different patients, if a sufficiently large group ( n =54) of persons were tested, it was shown to be feasible to compare potencies of sequential batches of the same specificity, and also of antigens of different specificities. It was shown that batches of mite extract were weaker than that of a grass pollen, but it proved to be a simple matter to adjust the concentration to give the same biological potency.