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Natural‐killer‐cell activity in atopic dermatitis
Author(s) -
LEVER ROSEMARY S.,
LESKO M. J.,
MACKIE RONA M.,
PARROTT DELPHINE M. V.
Publication year - 1984
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1984.tb02232.x
Subject(s) - atopic dermatitis , immunology , natural killer cell , peripheral blood , cell , medicine , biology , cytotoxicity , in vitro , biochemistry
Summary Natural‐killer (NK)‐cell activity was measured in the peripheral blood of twenty patients with atopic dermatitis and in a group of thirteen age‐matched non‐atopic controls (nine subjects on thirteen occasions). The method uses a chromium‐release assay with the human leukaemia cell line, K562, labelled with 5l Cr as the target cell. A highly significant reduction in NK‐cell activity was found in the patients with atopic dermatitis.