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Specific IgE antibodies in twenty‐eight workers with diisocyanate‐induced bronchial asthma
Author(s) -
PEZZINI ANGELA,
RIVIERA ANNAPIA,
PAGGIARO PIERLUIGI,
SPIAZZI ANNALISA,
GEROSA FRANCA,
FILIERI MARCELLA,
TOMA GIOVANNI,
TRIDENTE GIUSEPPE
Publication year - 1984
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1984.tb02229.x
Subject(s) - immunoglobulin e , asthma , medicine , immunology , occupational asthma , antibody , allergy
Summary A specific IgE‐mediated response was evaluated in twenty‐eight workers exposed to TDI or MDI, with diagnosis of occupational asthma and positive to bronchial provocative challenge. The presence of anti‐diisocyanate IgE was observed in 27% of subjects exposed to TDI and 83% of those exposed to MDI, particularly in individuals who experienced an acute massive exposure. An immediate‐type response to bronchial provocative test was found in 66% of individuals with specific antibodies. Specific IgE are prevalent (91%) in subjects who developed symptoms before 6 years of exposure to isocyanates. The results suggest an association between the presence of specific IgE, early asthmatic symptoms and heavy episodic exposure.