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Breast milk cell supernatants from atopic donors stimulate cord blood IgE secretion in vitro
Author(s) -
ALLARDYCE R. A.,
WILSON ANDREA
Publication year - 1984
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1984.tb02205.x
Subject(s) - cord blood , immunoglobulin e , immunology , lymphocyte , breast milk , medicine , atopy , secretion , antibody , endocrinology , biology , allergy , biochemistry
Summary Breast milk cell culture supernatants from atopic mothers (nineteen) were compared by ELISA with normal breast‐feeding controls (twenty‐one) for regulation of cord blood lymphocyte IgA and IgE secretion in vitro. A minority of atopic (five out of nineteen) and normal (three out of twenty‐one) cell supernatants stimulated cord blood lymphocyte IgA release to the same extent. The others were inactive. Stimulation was not related to breast milk cells donor atopic history or cord blood lymphocyte atopic heredity. In contrast, 70% of atopic milk cell supernatants stimulated cord blood lymphocyte cultures to form IgE ( x ± s.d. = 2070 ± 2240 pg/culture) while stimulatory supernatants (24%) from normal donors resulted in less lymphocyte IgE release (x ± s.d. = 680 ± 490 pg/culture) ( P < 0.001). These differences did not correlate with breast milk cell supernatant IgE concentrations, cord blood donor serum IgE levels or atopic heredity.