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Modulation by S‐adenosyl‐methionine and S‐adenosyl‐homocysteine of the human leucocytes histamine release
Author(s) -
PACHECO Y.,
MACOVSCHI O.,
BIOT N.,
FONLUPT P.,
PERRINFAYOLLE M.,
PACHECO H.
Publication year - 1984
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1984.tb02187.x
Subject(s) - histamine , homocysteine , chemistry , histamine n methyltransferase , methionine , pharmacology , biochemistry , medicine , histamine h2 receptor , receptor , amino acid , antagonist
Summary Methylation of membrane phospholipids is an important stage in the process of histamine release. This methylation reaction can be modulated by S‐adenosyl‐methionine (SAM) as well as by S‐adenosyl‐homocysteine (SAH). The influence of SAM and of SAH upon the histamine release of leucocytes from asthmatic and normal subjects were compared. In concentration of 10 ‐4 M, SAM enhanced spontaneous and the specifically induced histamine release. In concentration of 10 ‐5 M SAM enhanced the histamine release only in normals. This phenomenon could indicate a deficit in methyl‐transferase activity in the asthamatics. In concentration of 10 ‐4 M, SAH reduced spontaneous and specifically induced histamine release, having an effect comparable to that of 10 ‐4 M Theophylline.