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Clinical effects of hyposensitization using a purified allergen preparation from Timothy pollen as compared to crude aqueous extracts from Timothy pollen and a four‐grass pollen mixture respectively
Author(s) -
FROSTAD A. B.,
GRIMMER Ø.,
SANDVIK L.,
MOXNES A.,
AAS K.
Publication year - 1983
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1983.tb02609.x
Subject(s) - pollen , allergen , botany , aqueous solution , chemistry , biology , allergy , immunology , organic chemistry
Summary Most extracts used in hyposensitization are complex and ill‐defined mixtures of a large number of antigenic components. A highly refined (purified) and well‐characterized allergen preparation from Timothy pollen ( Phleum pratense ) is now available. This paper describes the results of hyposensitization for 3 years comparing the purified preparation Timothy N. the crude extract Timothy O and a four‐grass mix in sixty patients with allergic rhinitis due to grass pollen. The sixty patients were randomized into three groups and compared with a control group not hyposensitized. All three groups showed a significant decrease in clinical symptoms compared with the control group. The Timothy N group had a significantly higher nasal tolerance shown by nasal challenge test after 3 years' treatment than the group treated with the crude extract ( P = 0.05). In addition, the Timothy‐N‐treated patients needed significantly less antihistaminic medication than the patients having received the crude extract or the four‐grass mix ( P =0.02 and P = 0.01 respectively).