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Effect of prolonged venom immunotherapy on serum venom‐specific IgE and IgG
Author(s) -
CLAYTON W. F.,
REISMAN R. E.,
GEORGITIS J. W.,
WYPYCH J. I.,
ARBESMAN C. E.
Publication year - 1983
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1983.tb02604.x
Subject(s) - immunoglobulin e , venom , immunology , medicine , immunotherapy , antibody , allergy , atopy , biology , immune system , ecology
Summary Serum venom‐specific IgE and IgG were monitored in twenty‐three patients receiving venom immunotherapy for more than 3 years. Two response patterns of IgE antibody were found. Following initiation of therapy, seven patients had a rise in serum venom‐specific IgE, peaking at one year, then decreasing. Sixteen patients had a persistent fall in IgE antibody titres following initiation of therapy. At the end of 3 years, levels of serum venom‐specific IgE in both groups were comparable. The presence of atopy may have influenced the rising IgE antibody response. Serum venom‐specific IgG either rose or remained elevated if the pretreatment titres were high. After several years of therapy, there was generally a decrease in serum venom‐specific IgG.