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Stabilization of a diluted aqueous mite allergen preparation by addition of human serum albumin
Author(s) -
NAERDAL Å.,
VILSVIK J. S.
Publication year - 1983
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1983.tb02582.x
Subject(s) - allergen , human serum albumin , mite , bovine serum albumin , saline , chemistry , albumin , immunology , serum albumin , chromatography , egg albumin , phenol , allergy , medicine , biochemistry , biology , organic chemistry , botany
Summary Stability of diluted Spectralgen Dermatophagoides farinae allergen preparations in phenol‐saline with, and without human serum albumin (HSA) has been studied by intracutaneous tests in mite‐allergic patients. The phenol‐saline reconstituted mite allergen preparation lost activity to less than 1/10 of initial activity within 1 week, while mite allergen preparation reconstituted with solvent containing HSA was stable for at least 8 months after reconstitution. Human serum albumin probably prevents adsorption of allergens to glass surfaces which may be a problem for very diluted allergen preparations.