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Effect of house dust mite on serum complement activation and total haemolytic activity in vitro in normal subjects and in patients with bronchial asthma
Author(s) -
SRIVASTAVA NALINI,
GUPTA S. P.,
SRIVASTAVA L. M.
Publication year - 1983
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1983.tb02565.x
Subject(s) - asthma , medicine , immunology , house dust mite , mite , allergen , complement system , in vitro , methacholine , bronchial hyperreactivity , allergy , respiratory disease , antibody , chemistry , biology , lung , biochemistry , botany
Summary House dust mite ( Dermatophagoides farinae ) has been shown to activate the complement system in vitro by both the classical and alternative pathways in normal serum and in two groups of (skin test positive and skin test negative) patients with bronchial asthma. The activation was dose dependent in the lower range of allergen concentrations. Skin test positive asthmatic subjects showed the maximum activation. Skin test negative patients had activation between skin test positive patients and normal subjects. However, at the higher allergen concentration normal serum and bronchial asthma patients showed similar results.