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Transient bradycardia during vespid venom immunotherapy
Author(s) -
LYANGA J. J.,
McPHILLIPSFEENER S.,
WARRINGTON R. J.
Publication year - 1982
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1982.tb03130.x
Subject(s) - venom , bradycardia , immunotherapy , medicine , immunology , biology , heart rate , immune system , blood pressure , ecology
Summary A woman developed generalized symptoms of hypersensitivity when she was stung requiring treatment with adrenalin. Intradermal venom skin tests showed immediate hypersensitivity to yellow hornet and white‐faced hornet thus fulfilling the criteria to receive appropriate venom immunotherapy. During the course of modified rush immunotherapy with yellow hornet and white‐faced hornet venoms, she developed transient but progressive bradycardia necessitating interruption of the venom immunotherapy. Transient bradycardia recurred when venom immunotherapy was resumed but it was possible to reach a maintenance dose of 100 mg protein for each venom. Bradycardia has been reported to be induced in experimental animals by oriental hornet venom as well as other venoms, through a direct cholinergic action. It appears that a similar effect may occur in man in susceptible individuals during venom immunotherapy.