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Specific serum IgE antibodies to bacterial antigens in allergic lung disease *
Author(s) -
TEE ROSEMARY D.,
PEPYS J.
Publication year - 1982
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1982.tb01642.x
Subject(s) - allergic bronchopulmonary aspergillosis , medicine , immunoglobulin e , immunology , chronic bronchitis , streptococcus pneumoniae , cystic fibrosis , haemophilus influenzae , staphylococcus aureus , asthma , antibody , bronchitis , allergy , microbiology and biotechnology , biology , bacteria , antibiotics , genetics
Summary A radio‐allergosorbent test (RAST) to measure specific IgE antibodies in man to whole bacterial cells of Streptococcus pneumoniae , Staphylococcas aureus and Haemophilus influenzae was developed to investigate different well‐defined lung diseases (chronic bronchitis, allergic bronchopulmonary aspergillosis (ABPA), bronchial asthma, allergic rhinitis, cystic fibrosis) and also in urticaria as compared with non‐atopic blood donors, in addition, total IgE values and skin prick tests were assessed in these patients. The ABPA group gave the highest specific IgE RAST scores to all three bacteria. whilst the chronic bronchitis and cystic fibrosis groups also gave raised RAST scores with H. influenzae . There was a positive correlation between the patients' Sta. aureus and Str . pneumoniae immediate‐type skin reactions and their RAST scores and total serum IgE concentrations, but there was only a low incidence of immediate‐type skin test positivity to H. influenzae.

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