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Comparison of oral and inhaled metaproterenol for prevention of exercise‐induced asthma
Author(s) -
KÖNIG P.,
EGGLESTON P. A.,
SERBY C. W.
Publication year - 1981
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1981.tb02180.x
Subject(s) - medicine , exercise induced asthma , placebo , asthma , inhaler , anesthesia , terbutaline , alternative medicine , pathology
Summary The effectiveness of inhaled versus oral metaproterenol in preventing exercise‐induced asthma (EIA) was studied. Inhaled metaproterenol given 10 min before the exercise significantly reduced the degree of EIA in a group of twenty‐four patients, and in 75% of them completely prevented it. The mean percentage decrease in FEV 1 was 6‐5% with the inhaler and 30.1%, with placebo. When inhaled 1 hr before the exercise, metaproterenol was still better than placebo but its effectiveness was considerably lower. Metaproterenol tablets had a slight protective effect given I hr before, and none when administered 2 hr before exercise. There was no correlation between the protective effect against EIA and the bronchodilating effect obtained before exercise. Metaproterenol administered by metered‐dose inhaler is a very effective prophylactic medication against clinically troublesome EIA, while metaproterenol tablets should not be recommended for this purpose.