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Allergy to castor bean in The Sudan: measurement of serum IgE and specific IgE antibodies
Author(s) -
KEMENY D. M.,
FRANKLAND A. W.,
FAHKRI Z. I.,
TRULL A. K.
Publication year - 1981
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1981.tb01620.x
Subject(s) - immunoglobulin e , allergy , ascaris lumbricoides , immunology , medicine , castor oil , antibody , sensitization , biology , helminths , biochemistry
Summary Allergy to castor bean was diagnosed in thirty‐nine dockworkers from Port Sudan, on the basis of rhinitis and/or asthma provoked by castor bean dust, together with a positive prick test to a high dilution of castor bean extract. These were compared to twelve non‐allergic dockworkers from Port Sudan and forty‐three other Port Sudan residents. The castor bean allergic group had significantly higher IgE levels (mean 902 iu/ml) than the non‐allergic dock workers (mean 245 iu/ml) or the Port Sudan residents (mean 404 iu/ml) P <0.01, IgE antibody to castor bean was detected in all the castor bean‐allergic group, and also in 25‐35% of the Port Sudan resident group, but at a much lower level. No evidence was found to support the view that parasitic infestation (evidenced by IgE antibodies to Ascaris lumbricoides ) prevented sensitization to castor bean or any other allergen. There was a higher incidence of IgE antibodies to Dermatophagoides pteronyssinus in the castor bean‐allergic dockworkers (18/36) than in the non‐allergic Port Sudan residents (5/43), although we were unable to show that sensitivity to other inhalant allergens pre‐disposed to castor bean allergy.